Dr Michael Ladomery
Dr Michael Ladomery read Genetics at the University of Melbourne (1987-1990), and then undertook a PhD at the University of St Andrews (1991-1995) focused on the proteins involved in storing translationally repressed maternal mRNAs. After a one-year postdoc at the University of St Andrews funded by the Wellcome Trust focused on the RNA helicase Xp54/DHH1, he then worked as a Research Associate at the MRC Human Genetics in Edinburgh (from 1996-2002; and as Senior Research Associate from 2000). At the MRC HGU, Michael worked on the posttranscriptional roles of the tumour suppressor WT1. In 2002 he moved to U.W.E. Bristol where he was appointed as a Senior Lecturer; then as Reader from 2010.
His research area is RNA Biology, with a current focus on alternative splicing in cancer (www.ladomerylab.org). He runs the Southwest UK RNA Club and has published the first comprehensive RNA Biology Textbook (Elliott and Ladomery, Molecular Biology of RNA, O.U.P. 2010). Highlights of his research include the first use of siRNA ex vivo (knocking down WT1 during kidney development); a demonstration that WT1 binds mRNA in vivo with a central role for zinc finger one; an analysis of the human Denys Drash Syndrome podocyte proteome; and a recent Cancer Cell paper in which targeting the splice factor kinase SRPK1 results in the inhibition of angiogenesis in vivo.
Page updated: 21 October, 2012